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Colchicine is a natural alkaloid that can be indicated for prophylaxis and treatment of gout. It mainly acts by inhibition of inflammatory cascade thereby reduces gouty attacks. #prophylactic #gout #caspase
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Gout Pharmacology. Following hyperuricemia, the urate crystals get deposited in the joints and connective tissues and activate monocytes or macrophages via Toll-like receptor pathway mounting and innate immune response. This results in secretion of cytokines including interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) leading to endothelial activation and attraction of neutrophils to the site of inflammation. Neutrophils secrete inflammatory mediators that create an acidic environment, which further causes precipitation of urate crystals. Colchicine is used to prevent or treat attacks of gout (also called gouty arthritis). This condition is caused by too much uric acid in the blood. An attack of gout occurs when uric acid causes inflammation (pain, redness, swelling, and heat) in a joint. Colchicine does not cure gout, but it will help prevent gout attacks. Colchicine is not an ordinary pain reliever and will not relieve most kinds of pain. Colchicine is also used to treat a rare condition called familial Mediterranean fever (FMF). Colchicine may be used in 2 ways. Most people take small amounts of it regularly for a long time (months or even years) to prevent severe attacks or other problems caused by inflammation. Other people take large amounts of colchicine during a short period of time (several hours) only when the medicine is needed to relieve an attack that is occurring. The chance of serious side effects is much lower with the first (preventive) kind of treatment. Because some of colchicine's side effects can be very serious, you should discuss with your doctor about the benefits as well as the risks of using this medicine. This medicine is available only with your doctor's prescription. This product is available in the following dosage forms: Capsule Solution Tablet Gout is a metabolic disorder characterized by hyperuricemia. Asymptomatic hyperuricemia ought not to be treated until arthritis; renal calculi or tophi become evident. The cornerstone of therapy of acute attack is often nonsteroidal anti-inflammatory drugs (NSAIDs), barring specific situations wherein colchicine and corticosteroids do have a role. Usually NSAIDs with stronger anti-inflammatory action are used in high and quickly repeated doses and have a slower response response as compared to colchicine, they are better tolerated. Colchicine has a unique mechanism action. Intra-articular corticosteroids provide relief in acute attack and are given in patients having inability to tolerate NSAIDs and colchicine. Chronic gout requires treatments with drugs that either promote excretion (e.g., probenecid, lesinurad) or prevent its synthesis through inhibition of enzyme xanthine oxidase (allopurinol, febuxostat, etc.). Pegloticase and rasburicase, being a recombinant uricase enzyme, oxidize uric acid to highly soluble allantoin excreted in urine. In spite of these effective treatment modalities, question arises on their safety profile. Newer treatment options are being extensively studied especially interleukin-1 (IL-1) inhibitors but their approval is still pending. The quest for an optimally designed drug with desirable efficacy and acceptable safety profile is still on. Thank you for watching the video. Subscribe to support channel 👉 - RELATED VIDEOS .... 👉 👉 Phone: Email: Facebook: ✔️. Copyright belongs to Channel ✔️. Representative: ⛔️. Copyright by ⛔️. Don't Reup #
A drug to treat gout and other diseases, taken by mouth. The molecular pathology of acute inflammation associated with gouty arthritis involves several concurrent pathways triggered by a variety of interactions between monosodium urate crystals and the surface of cells. It works by decreasing inflammation. It binds to tubulin which is essential to microtubule polymerization in mitosis, and thereby disrupts inflammasome activation, microtubule-based inflammatory cell chemotaxis, generation of leukotrienes and cytokines, and phagocytosis. It inhibits activation and migration of neutrophils to sites of inflammation, leading to a net anti-inflammatory effect to ease gout inflammation. (Manifestation to treat) • gout: Less preferred to NSAIDs or steroids. • Behçet's disease • pericarditis • familial Mediterranean fever It has a narrow therapeutic index, so overdosing is a significant risk. Side effects can result from inhibition of mitosis. The poisoning by overdose begins with a gastrointestinal phase occurring 10-24 hours after ingestion, followed by multiple organ dysfunction occurring 24 hours to 7 days after ingestion. After that, the affected person either declines into multiple organ failure or recovers over several weeks. It interacts with the P-glycoprotein transporter and Cytochrome P450 3A4 (CYP3A4), which drugs such as erythromycin and clarithromycin inhibit, leading to death. It should not be given to people taking macrolide antibiotics, ketoconazole, or cyclosporine, or those who have liver or kidney disease, as colchicine blood levels is raised because its metabolism is interfered, potentially increasing its toxicity abruptly. (Side effects) Moderate doses: • gastrointestinal upset, diarrhea • neutropenia High doses: • anemia caused by damage of bone marrow • multiple organ dysfunction: kidney damage, low white blood cell counts, anemia, muscular weakness liver failure, hepatomegaly, bone marrow suppression, thrombocytopenia, ascending paralysis • alopecia (hair loss) • neuromuscular toxicity: seizures, confusion, delirium, hallucinations in children • rhabdomyolysis: A life-threatening condition caused by muscle breakdown and muscle death. • hypovolemic shock: Due to extreme vascular damage and fluid loss through the gastrointestinal tract, which can be fatal.
Colchicine is used to prevent or treat gout attacks. Gout is an inflammatory arthritis that is the result of the precipitation of serum urea into crystalized deposits of monosodium urea (MSU) in and around the joint. These crystals cause sever inflammatory arthritis, which is initiated by mechanisms involving various proinflammatory mediators, such as cytokines and chemokines. Colchicine affects the molecular pathology of gouty arthritis. And prevents the formation of microtubules. Colchicine interferes with the inflammatory molecules found in neutrophils and monocytes. Colchicine binds to both α- and β-tubulin to create a tubulin–colchicine complex that prevents the formation of microtubules. The state of microtubule polymerization can control numerous cellular functions, including intracellular organelle and vesicle transport secretion of cytokines and chemokines and migration, division, and regulation of gene expression. These actions influence the cell activity known to be involved in inflammatory pathways central to the pathogenesis of gout. However, with overdose, Colchicine becomes toxic as an extension of these mechanisms. The adverse effects and toxicities of colchicine are gastrointestinal upset renal failure neutropenia damage bone marrow (anemia) neuromyopathy and rhabdomyolysis death(accidental and intentional) (Reference) Drug bank. “Colchicine” drugbank.ca Dalbeth N, Lauterio TJ, Wolfe HR. Mechanism of action of colchicine in the treatment of gout. Clin Ther. 2014 Oct 1;36(10):1465-79. doi: 10.1016/j.clinthera.2014.07.017. Epub 2014 Aug 21. PMID: 25151572 DOI: 10.1016/j.clinthera.2014.07.017 3. Cronstein, B.N., Molad, Y., Reibman, J. et al. Colchicine alters the quantitative and qualitative display of selectins on endothelial cells and neutrophils. J Clin Invest. 1995; 96: 994–1002 4. Yanqi Xie, Liliia M. Kril, Tianxin Yu, Wen Zhang, Mykhaylo S. Frasinyuk, Svitlana P. Bondarenko, Kostyantyn M. Kondratyuk, Elizabeth Hausman, Zachary M. Martin, Przemyslaw P. Wyrebek, Xifu Liu, Agripina Deaciuc, Linda P. Dwoskin, Jing Chen, Haining Zhu, Chang-Guo Zhan, Vitaliy M. Sviripa, Jessica Blackburn, David S. Watt & Chunming Liu Semisynthetic aurones inhibit tubulin polymerization at the colchicine-binding site and repress PC-3 tumor xenografts in nude mice and myc-induced T-ALL in zebrafish Scientific Reports 9, Article number: 6439 (2019) 5. Ivana Spasevska , Ahmed T. Ayoub , Philip Winter , Jordane Preto , Gane K.-S. Wong , Charles Dumontet and Jack A. Tuszynski Modeling the Colchicum autumnale Tubulin and a Comparison of Its Interaction with Colchicine to Human Tubulin Int. J. Mol. Sci. 2017, 18(8), 1676; 🤍 6. Finkelstein Y, Aks SE, Hutson JR, Juurlink DN, Nguyen P, Dubnov-Raz G, Pollak U, Koren G, Bentur Y (June 2010). "Colchicine poisoning: the dark side of an ancient drug". Clinical Toxicology. 48 (5): 407–14. doi:10.3109/15563650.2010.495348. PMID 20586571. (Picturtes) 1. Structure of Colchicin By Jynto (talk) - Own work. This image was created with Discovery Studio Visualizer., CC0, 🤍 2. Gout. Mayo Clinic mayoclinic.org 3. Bobjgalindo Spiked rods of monosodium urate crystals photographed under polarized light from a synovial fluid sample. Formation of monosodium urate crystals in the joints are associated with gout. (movies) Pixabay (music) youtube free music
Colchicine remains one of the traditional medicines used to treat acute flares of gout. The current preferred treatment involves a low dose of 2 tablets at the first twinge of joint pain followed by one additional pill 60 minutes later. At this dose many of the unwanted side effects of previously popular higher dose therapy with colchicine may be avoided. While gout remains the most common indication for colchicine, recent investigations shed light on its potential to prevent heart attacks, stroke and other cardiovascular disease. A study of colchicine presented at the American Heart Association meeting in 2013 demonstrated dramatic improvement in these conditions. Another larger study published in late 2019 revealed a 74% reduction in stroke and a 50% decrease in urgent hospitalizations for chest pain requiring revascularization in a population at elevated risk. Colchicine also seems to provide significant protection against recurrent atrial fibrillation following radiofrequency ablation. Another benefit of colchicine involves prevention of inflammation of the sac around the heart or pericarditis. Unfortunately colchicine may be associated with a wide range of adverse effects even including an occasional death. Careful consideration of kidney and liver function is mandatory along with evaluation of any drugs that may increase the risk of colchicine's side effects.
Colchicine na gamot sa gout, posibleng mapababa ang komplikasyon o tsansang mamatay sa COVID, ayon sa Montreal Heart Institute Unang Balita is the news segment of GMA Network's daily morning program, Unang Hirit. It's anchored by Arnold Clavio, Susan Enriquez, Ivan Mayrina, Connie Sison, and Mariz Umali, and airs on GMA-7 Mondays to Fridays at 5:30 AM (PHL Time). For more videos from Unang Balita, visit 🤍 For the latest updates about the COVID-19 pandemic (coronavirus disease 2019), click this link: 🤍 You can watch 24 Oras and other Kapuso programs overseas on GMA Pinoy TV. Visit 🤍 to subscribe. GMA promotes healthy debate and conversation online. Any abusive language that does not facilitate productive discourse will be blocked from this post. Subscribe to the GMA News channel: 🤍 Visit the GMA News and Public Affairs Portal: 🤍 Connect with us on: Facebook: 🤍 Twitter: 🤍 Instagram: 🤍 #GMANews
Colchicine is a drug with anti-inflammatory properties that comes from the autumn crocus, a plant with purple flowers. It is efficient to treat or prevent gout, Familial Mediterranean Fever, acute pericarditis and certain cardiovascular problems. The goal of the COLCOT-T2D study by Dr. Jean-Claude Tardif, Director of the Montreal Heart Institute’s Research Centre, is to demonstrate that colchicine can prevent cardiovascular diseases in diabetics. Discover the current research project: 🤍 _ Do you care about patients and want to support research? Donate today: 🤍 Follow us on social media: Facebook: 🤍 LinkedIn: 🤍 Since 1977, the Montreal Heart Institute Foundation has been striving to turn dreams into reality for the team at the Institute, helping them to push the boundaries of research, care, prevention and teaching. To find out more about the Foundation: 🤍
Did you know many adult prescription medications can be very dangerous if taken in higher doses than prescribed — even fatal if ingested by children? In this Poison Prevention Week 2021 video, Sarasota Memorial Pharmacy Resident Kyle Stupca, PGY2, warns us about the potential dangers of the anti-inflammatory Colchicine and other prescription medications. Get more poison prevention tips at smh.com/blog.
PHARMACIST Fi shares the fascinating ways a medicine called colchicine works to reduce inflammation for people with gout. (Some colchicine brand names you might recognize include: Colcrys, Mitigare, or Gloperba in U.S.A.; Colgout, Lengout, or Colcine in Australia.) Please also watch PHARMACIST Fi's 2 main videos on colchicine for gout: 'Part 1' (via the following link) looks at important things for you and your doctor to talk about before starting colchicine, or when already taking colchicine: 🤍 & 'Part 2 (Coming soon!) Looks at ways to try to prevent side effects and medicine interactions with colchicine. Here is the link to the PHARMACIST Fi video about CMIs: 🤍 Here is a link to a PHARMACIST Fi video about medicine interactions (this video has general info and is not specific to colchicine), in case it may also be of interest to you: 🤍 We hope this info has been helpful for you! Please also see the disclaimer at the end of this video.
Friendly Pharmacy 5 Channel: 🤍 Colchicine youtube link: 🤍 Colcorona trial: 🤍 Mouthwash: A Recommendation of PHTALOX ® Mouthwash for Preventing Infection and Progression of COVID-19: 🤍 Vitamin D replacement enhances antigen-specific immunity in older adults: 🤍
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Colchicine is a generic medication, and has ben around a long time. It has been used to fight inflammation in Gout, and has been hypothesized to decrease chance of heart attack. I go through a brief description of the trials, and at the end give you my opinion of use of Colchicine in heart disease.
Déjà connue pour son efficacité contre certaines maladies comme la goutte, la colchicine pourrait bien aider à diminuer les hospitalisations et les décès, selon une nouvelle étude. Mais son utilisation doit être mesurée.
A recent study in the journal Rheumatology has found that Colchicine use may lower the risk of chronic kidney disease (CKD) progression, chronic kidney disease progression was defined as morethan or equal to 40% decrease from the baseline estimated glomerular filtration rate or the onset of kidney failure with replacement therapy. Get the latest medical and heath news at medicaldialogues.in Follow us on Twitter: 🤍 Facebook: 🤍 Instagram: 🤍 LinkedIn: 🤍 Website: 🤍
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PHILADELPHIA Low dose colchicine (Colcrys) appears to be as effective as high doses of the drug in reducing the pain of gout with fewer advers side effects, a researcher said here. Medpage Today: 🤍 Online CME - Continuing medical education: 🤍 Latest medical news: 🤍 The MedPage Today app: iOS: 🤍 Android: 🤍 MedPage Today Youtube Channel: 🤍 Medpage Today on Facebook: 🤍
Study this Colchicine mnemonic and other mnemonics with Pixorize. Colchicine is an anti-inflammatory drug used to treat gout, a type of arthritic inflammation. Colchicine achieves this reduction in inflammation by blocking microtubule polymerization, which impairs the inflammatory response of neutrophils. Clinically, colchicine is first-line in the acute treatment of gout flares, along with NSAIDs. Patients taking colchicine commonly experience GI side effects like abdominal pain, as well as nausea and vomiting. Subscribe for more: 🤍 Study interactive image: 🤍 #USMLE #Step1 #Pharm #colchicine #gout
#FrontlinePilipinas | Nagbabala ang DOH laban sa paggamit ng gamot sa gout na Colchicine bilang lunas sa COVID-19. | via JC Cosico Follow News5 and stay updated with the latest stories! Facebook: facebook.com/News5Everywhere Twitter: twitter.com/News5PH Instagram: 🤍news5everywhere Website: news5.com.ph
Contributor: Don Stader, MD Educational Pearls: 1. Gout is an arthritis caused by the deposition of urate crystals into the joint space 2. Colchicine works by disrupting microtubules and prevents white blood cells from getting into the joint space which stops the inflammatory response 3. Colchicine has a high rate of adverse events, in particular explosive diarrhea 4. The drug also has a very narrow therapeutic index and overdose is nearly universally fatal, with no antidote or effective treatment option available 5. Alternative agents such as steroids, which reduce the inflammatory response to urate crystals, along with NSAIDs may be better options for treatment References Angelidis C, Kotsialou Z, Kossyvakis C, et al. Colchicine Pharmacokinetics and Mechanism of Action. Curr Pharm Des. 2018;24(6):659-663. doi:10.2174/1381612824666180123110042 Finkelstein Y, Aks SE, Hutson JR, et al. Colchicine poisoning: the dark side of an ancient drug. Clin Toxicol (Phila). 2010;48(5):407-414. doi:10.3109/15563650.2010.495348 Dalbeth N, Merriman TR, Stamp LK. Gout. Lancet. 2016;388(10055):2039-2052. doi:10.1016/S0140-6736(16)00346-9 Summarized by Jackson Roos, MS4 | Edited by Erik Verzemnieks, MD The Emergency Medical Minute is excited to announce that we are now offering AMA PRA Category 1 credits™ via online course modules. To access these and for more information, visit our website at 🤍 and create an account. Donate to EMM today: 🤍 Episode Link on Website: 🤍
Massimo Imazio (Turin, Italy) discusses with Dejan Milasinovic the results of the LoDoCo2 trial which showed that Colchicine reduces the risk of major cardiovascular events in patients with chronic coronary disease. Prof. Imazio answers the following questions: - What is the role of Colchicine in coronary artery disease? - Could you talk about the LoDoCo1 trial which preceded LoDoCo2? - Could you describe the design and the main results of LoDoCo2? - What are the clinical implications in terms of side effects? - Do you think the results may be applied to patients with chronic coronary syndrome who have had previous history of ACS? More news for the interventional cardiovascular community on PCRonline: 🤍 #ESCCongress
By Brad Langford, BScPhm, ACPR, PharmD, BCIDP DISCLAIMER: This presentation is posted on behalf of the Society of Infectious Diseases Pharmacists (SIDP), which is a non-profit organization of 1500+ pharmacists specializing in infectious diseases pharmacotherapy. Please note the following regarding this educational video: 1) The presenter is a vetted expert in infectious diseases pharmacotherapy and qualified to give this presentation based on training and practice experience. 2) The information in this presentation is not intended to provide medical advice. We advise that patients always consult with a licensed healthcare provider before making individual decisions regarding their healthcare, or the use of any agents or therapies described in this presentation. 3) The information in this presentation is intended to educate healthcare providers regarding appropriate use of this agent, specifically in the context of considered treatment of COVID-19 infection. Providers should always consider the benefits and risks for each individual patient before making patient-specific healthcare decisions. 4) All information provided in this presentation is cited from published medical evidence or other verifiable sources. Any expert opinion is identified as such within the presentation for purposes of transparency. 5) The information in this presentation is not intended to endorse or promote the use of any specific commercial product. Providers should always consider the risks and benefits associated with any particular product prior to making patient-specific decisions. To learn more about SIDP and our COVID-19 Resources, please visit sidp.org/covid19/ and/or follow our verified social media account, 🤍SIDPharm, on Twitter.
Read the research: 🤍 In this 1-minute video, Prof. Christopher C Butler explains: – Colchicine is used regularly for treating gout – Side effects are gastrointestinal; it is an anti-inflammatory – Results were available quickly due to the trial design – Colchicine did not speed up recovery from COVID-19 – The PRINCIPLE trial gives rapid answers within the pandemic – Trial design is flexible, adapting to different treatments – PRINCIPLE is transforming research in primary care Listen to the full podcast interview: 🤍
Study this Colchicine NCLEX mnemonic and other mnemonics with Pixorize. Colchicine is an anti-inflammatory medication that is used to reduce inflammation, treating acute gout attacks and pericarditis. The biggest side effect to know is gastrointestinal distress. Colchicine may be taken with food to relieve GI discomfort. Subscribe for more: 🤍 Study interactive image: 🤍 #Colchicine #NCLEX #AntiInflammatory
The government may allow clinical trials for colchicine, a drug believed to be effective for treating Covid-19, Health Chief Francisco Duque III said Wednesday. Video by PTV Visit us at 🤍 Facebook: 🤍 Twitter: 🤍
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Although unapproved colchicine has been used for many years, FDA approved the first single-ingredient oral colchicine product, Colcrys, in July 2009 for the treatment of familial Mediterranean fever (FMF) and acute gout flares; in October 2009 Colcrys was approved for prophylaxis of gout flares (chronic gout). The approved prescribing information for Colcrys includes a new drug interaction warning, updated dosing recommendations and a medication guide. Pharmacists are reminded to dispense only FDA approved products. FDA Drug Info Rounds pharmacists discuss the differences between approved and unapproved colchicine products, concerns regarding unapproved single-ingredient oral colchicine, and how patients can offset the increased cost of Colcrys. For more information, please see our website: 🤍 [vpdrugs]
Dropping Drugs presents an information burst covering Colchicine which is branded as; Goutnil Cochic Artrex Tolchicine Colgout Colgout CP-Colchi Lengout Recolfar Colchiquim Goutichine Colcina Comments are active, but are not actively monitored. If you wish to contact us please use the email address attached to this account. A pharmacist has reviewed and released this episode. Information is intended for a United Kingdom audience and supports common travel requirements. All technical definitions are those defined by European Medical agency (ema) but where possible or where it is the norm those relevant to best practice have been used as defined by the federal drug administration (FDA). Common and less common adverse effects are listed to highlight the health professionals opinion of the most commonly observed side effects. Not all documented adverse effects are reported. Where legal status for a medicine varies, the most common treatments legal status is often used to indicate the need for a prescription. Where national differences apply national flags may be used to indicate such a region All rights to Brand names are retained by the respective companies. Carefree Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 3.0 License 🤍 The royal pharmaceutical Society of Great Britain owns rights to a registered service mark – ‘Pharmacy Green Cross’. Dropping drugs was produced on behalf of AJI Technology who reserve all rights 2016. Patients are advised to seek individual medical advise and read the patient information leaflet prior to initiation of any treatment Consider translating into your language, because we would like this to be as useful as possible… a big thank you. 🤍 Episode 14
PHARMACIST Fi shares some fascinating info about a medicine for gout called colchicine (some colchicine brand names you might recognize include: Colcrys, Mitigare, or Gloperba in U.S.A.; Colgout, Lengout, or Colcine in Australia), in this first episode of her 2-part series of 'Some Need-to-Know Info!' about colchicine. Part 1 has a particular focus on things to talk about with your doctor before taking colchicine (many of which are also relevant to people who are already taking colchicine). Please note that the info in this series of colchicine videos and in this description section is for people taking colchicine for gout (not for people taking colchicine for other medical conditions). Please also note: PHARMACIST Fi recommends making medicine decisions together with a doctor - not on your own. Part 2 of this series (coming soon!) will look at potential side effects of colchicine - some of which are serious - so, although (thankfully!) most people on modern [lower] gout dose schedules do not get side effects - it is important to find out what side effects to look out for, because if they did happen, some of them would need emergency medical attention. Part 2 of this series will also cover 3 good ways to try to avoid potentially life-threatening medicine interactions between colchicine and certain other types of medicines (e.g. the antibiotic clarithromycin). Here is a link to the video PHARMACIST Fi mentions about why you need a CMI for each medicine you take (a CMI is 'Consumer Medicine Information', which is called a 'Medication Guide' in the U.S.A. or 'Patient Information Leaflet' (PIL) in the U.K.; each medicine has its own CMI, which either comes with the medicine, or can be printed or emailed to you by a pharmacist or doctor): 🤍 & here is a link to PHARMACIST Fi's video about why you need a 'Medicines, Allergies & Contacts List' - and to give an updated copy of it to each person who prescribes medicines or other health products for you (e.g. doctors, specialists, pharmacists, dentist, nurse, etc.) while you are taking colchicine - to try to reduce risk of a medicine interaction: 🤍 We hope this info is helpful for you. Please also read the disclaimer at the end of the video.
Dans l’espoir de déterminer si un traitement à court terme réduirait le risque de complications pulmonaires et de décès liés à la COVID-19, des chercheurs québécois commencent dès lundi à recruter 6000 Canadiens atteints du nouveau coronavirus dans le cadre d'une étude clinique d’envergure. 🤍
Principal investigator Binita Shah, MD, MS explains the results from Cochicine-PCI. Dr, Shah is an interventional cardiologist with NYU Langone Health. See this study and other late-breaking science presentations on our #AHA Science News page: 🤍
In this episode, I discuss a medication known as colchicine (Colcrys). My book is now available! It discusses my experience with Bipolar Disorder. The Fifth Episode - Inside The Manic Mind. Find it here: BookBaby (best way to support this project): 🤍 Amazon: 🤍 Barnes & Noble: 🤍 Support the channel on Patreon: 🤍 Twitter: 🤍talkaboutdrugs Instagram: 🤍garrett.campb Connect on Facebook: 🤍 For information purposes only!
Colchicine for Recurrent AF after Ablation